Just under one in six of England’s adult population are on antidepressants, while one in ten admit to using illegal drugs. This crossover poses a few potential problems: when combined, antidepressants and recreational drugs come with their own set of side-effects and risks. But even though there are strong links between drug use, dependence and depression, there is little information out there about what happens to your body when you mix these drugs. Tom, 25, was on antidepressants from the age of 16 to 22, and used to smoke weed daily. Different drugs and doses will react in different ways to varying types of antidepressants.